In my backyard, my biggest mango tree soars up into the sky. Just one mature tree can yield up to 300 pounds of fruit.

But as much as I enjoy the fruit... I’m not here to talk about the mango itself.

Today, I want to talk about the leaves. Because that’s where the real magic happens.

You see, there is a compound inside the leaves called mangiferin that can help you grow new brain cells.

It works by turbocharging a brain chemical called brain-derived neurotrophic factor (BDNF).

And that makes it a game-changer for your brain.

Let me show you what I mean...

For decades, scientists insisted that it was impossible for your brain to form new neurons — especially in the part of the brain responsible for learning and memory.

But they were wrong.

Today, thanks to a breakthrough study done in 1998 — that’s less than 30 years ago! — we now know that not only is it possible to form new brain cells through a process known as neurogenesis...

But you can also help your existing neurons grow bigger and become more active.1

Sadly, most conventional doctors still insist that forgetfulness, mental fatigue, and fuzzy thinking are just “a normal part of aging.” That’s the usual response from mainstream medicine.

But it’s just not true.

You can easily activate neurogenesis to eliminate brain fog and to stop — and even reverse — memory loss.

What We Can Learn From “Super-Agers”

An exciting new study is shedding light on how a group of “super-agers” are keeping their brains active and strong.

“Super-ager” is a term for someone whose brain is aging at a rate that’s much slower than average.

In a study published in The Journal of Neuroscience, scientists found that neurons in the area of the brain responsible for memory were noticeably larger in super-agers compared to their peers.2

In fact, the super-agers had larger neurons than some individuals who were 20 to 30 years younger!

The researchers examined neurons located in the entorhinal cortex. That’s the area of the brain whose functions include memory.

The super-agers, who were 80 and older, were compared to cognitively average individuals and those with early-stage Alzheimer’s.

In addition to being large and healthy, the neurons found in the superagers’ brains were relatively free of tau tangles, one of the classic hallmarks of cognitive decline.

Turns out these superagers had turbocharged their brain’s production of BDNF.

A recent study found that people with the highest levels of BDNF develop dementia 50% less often than people with lower levels.

This signaling protein and growth factor is like a “growth hormone” for your brain.

It increases the creation and growth of nearly every type of neuron. It also increases the lifespan of existing neurons.3

One study showed that people with the highest levels of BDNF develop dementia 50% less often than people with lower levels.4

Low Levels of BDNF Lead to So-Called “Senior Moments”

You see, these “senior moments” are not symptoms of aging. They’re symptoms of low levels of BDNF.

BDNF is a signaling protein and growth factor that supports the growth, function, and survival of brain cells. Your brain can’t generate new neurons or make new connections between them without it.5

When patients at my clinic complain they’re losing their car keys daily or walk into rooms and forget why they’re there, one of my first courses of action is to boost their BDNF.

More than 2,000 peer-reviewed studies link BDNF levels to brain performance, mood, and long-term neurological health.

Researchers have even discovered that the world’s longest-living people all share dietary and lifestyle habits that support high BDNF levels.6

The good news is that it’s easy to raise your levels through diet and supplements.

Here at the Sears Institute for Anti-Aging Medicine, I’ve found that boosting BDNF is the single most powerful way to protect your brain, sharpen your mind, and reverse cognitive decline.

Studies reveal that foods that contain a group of biochemicals called anthocyanins can turbocharge your brain’s production of BDNF.

Consuming grass-fed beef and wild-caught salmon — containing omega-3 fatty acids — are other great ways to boost your BDNF levels.7

Now imagine a massive blackout. Lights go out. Communication lines fail. Transportation shuts down. The whole city grinds to a halt.

BDNF decline is the brain drain that no one in mainstream medicine is talking about...

Sadly, this key brain protein begins to drop off around age 30. By the time you hit your 60s, your levels may have declined by more than 50%.

Once the decline starts, your brain becomes vulnerable to memory loss, brain fog, depression, mental fatigue, and neurodegeneration.8

That’s because when your BDNF levels drop...

  • Your neurons shrink and die

  • Your brain can’t form or recall memories

  • Synaptic communication fails

  • Emotional regulation goes haywire

  • Neurodegenerative diseases take root

In fact, brain scans show that people with low BDNF have shrunken hippocampi — the area of the brain that’s responsible for memory and learning.

But higher levels of BDNF produce polar opposite effects. BDNF can light up your brain like a Christmas tree.

Increase BDNF To Build New Brain Cells

From the experiences in my clinic, I’ve found the fastest way to bring someone back from the brink of cognitive decline — whether they’re struggling with brain fog and memory loss or they’re experiencing the early signs of Alzheimer’s and Parkinson’s — is to increase their BDNF levels.

Research now reveals that BDNF-boosting foods can be potent weapons against a range of neurodegenerative conditions.

In one study, BDNF-boosting supplements helped reduce brain-cell damage from Parkinson’s.9

Researchers have also found that people with Alzheimer’s have lower levels of BDNF than healthy individuals, and that a BDNF-boosting diet can help prevent the condition.10

Here’s what BDNF does to your brain:

  • Builds New Brain Cells. BDNF activates a process called neurogenesis — the birth of new neurons. For decades, scientists believed we were born with all the brain cells we’d ever have. That’s flat-out false. Your brain can—and will — grow new cells for the rest of your life. But only if BDNF is present.11

  • Strengthens Synaptic Connections. Learning, memory, mood regulation and critical thinking all depend on the strength of your synaptic connections — the way your neurons communicate with one another. BDNF improves the density, speed, and efficiency of these connections. The more BDNF you have, the faster and clearer your thoughts become.12

  • Protects Against Alzheimer’s And Neurodegeneration. Low levels of BDNF have been linked directly to Alzheimer’s disease, Parkinson’s, as well as other forms of neurodegeneration. Researchers have also observed that people with the lowest BDNF levels are up to four times more likely to develop Alzheimer’s.13

  • Fuels Mental Energy And Motivation. Have you ever felt too exhausted to think? Have you struggled to stay motivated or inspired or focused? BDNF activates areas of your brain like the prefrontal cortex and limbic systems. These are the centers responsible for planning, motivation, and emotional balance. When BDNF levels drop, your brain becomes sluggish... your emotions go flat... and everything feels like a chore.14

  • Helps You Recover From Stress And Trauma. BDNF increases your brain’s resilience. It helps you bounce back from trauma, regulate anxiety, and protect yourself from the long-term effects of chronic stress. Low BDNF has been implicated in depression, PTSD, and burnout.

Boost Your Mind with Mango Leaf Extract

Unlike most neurotransmitters, BDNF is amazingly responsive to lifestyle changes.

I recommend incorporating healthy habits — like regular vigorous exercise, an omega-3 rich diet, increasing the amount of polyphenols you eat, maintaining strong social ties, managing stress, and supplementation — into your daily life.

But you can do even better.

Because your brain is not broken... It’s starving for the right nutrients.

Scientists have discovered a potent polyphenol that supercharges BDNF in a mango leaf compound called mangiferin.

In studies, it was found to unlock the very pathways conventional medicine swears are “impossible” to influence.

Research shows that the mangoferin in mango leaf extract:15,16

  • Boosts cognitive function

  • Improves concentration

  • Increases working memory

  • Enhances reaction time

Here’s how it works...

It Calms the Brain’s Fire. Inflammation is the true killer of neurogenesis. But mangiferin acts like a biological fire-extinguisher — suppressing TNF-α, IL-6, and COX-2, while restoring the calm environment your brain needs to rebuild itself.

It Shields Your Neural Stem Cells From Oxidative Assault. Your brain’s newborn cells are fragile. One burst of oxidative stress can destroy them before they mature. Mangiferin boosts your natural antioxidant defenses — SOD, catalase, and glutathione — giving your brain cells a protective armor conventional drugs can’t match.

It Provides Fuel for a Growing Brain. Neurogenesis is energy-intensive. Mangiferin stabilizes your mitochondria, improves ATP production, and keeps your neural power plants humming—so your new neurons have the energy to grow strong and stay alive.

The result is a brain that can renew itself.

Researchers have documented real, physical regeneration:

  • More hippocampal neurons

  • Better memory and learning

  • Protection from neurodegeneration

  • Reversal of toxin-induced neuron loss

All from a natural compound Big Pharma can’t patent — and therefore refuses to talk about.

Studies Back Up Mangiferin’s Brain-Boosting Benefits

Recent studies back up mangiferin’s brain-enhancing benefits.

In one study, participants were divided into four groups. Each group was given mango leaf extract, caffeine, both, or a placebo.

The patients who supplemented with mango leaf extract had increased activity in all four regions of the brain associated with cognitive processing, attention, and memory.

The mango leaf group also saw a striking 47% reduction in brain fatigue and a 5% improvement in reaction time.17

The mango leaf participants’ results were “significantly” better than the results observed in subjects who took caffeine alone or took a combination of caffeine and mango extract.

In a second study, published in the journal Nutrients, researchers showed that people who supplemented with 300 mg of mangiferin experienced significant improvements in focus, alertness, and reaction time.18

Banish Brain Fog and Increase Focus

In traditional cultures, young mango leaves are picked fresh from the tree. Then they’re added to curries or served with fish. They bring a sweet mango-like flavor to the food.

I like to make mango leaf tea the same way they do in India. Here’s an easy recipe you can try today.

Ingredients:

  • 10 to 15 fresh mango leaves, washed

  • ½-inch piece of ginger root, thinly sliced

  • ½ Tbsp raw honey

  • 8 ounces of water

Directions:

  1. Wash the leaves and tear them into small pieces.

  2. Bring a pot of water to boil on the stove. Add ginger root, cover, and boil for 5 minutes.

  3. Add the leaves and remove the pot from the heat.

  4. Steep for 10 minutes, then strain.

  5. Pour into a cup and add honey to sweeten.

You can also take mango leaf extract as a supplement.

Look for one that comprises 60% or more mangiferin. I recommend taking 300 mg once daily.

To Your Good Health,

References:

  1. Weintraub K. “The Adult Brain Does Grow New Neurons After All, Study Says.” https://www.scientificamerican.com.

  2. Nassif C, et al. “Integrity of neuronal size in the entorhinal cortex is a biologic substrate of exceptional cognitive aging.” J Neurosci. 2022 Sep 26;JN-RM-0679-22.

  3. Heisz J, et al. “The effects of physical exercise and cognitive training on memory and neurotrophic factors.” J Cogn Neurosci. 2017; 29 (11):1895-

  4. Weinstein G, et al. “Serum brain-derived neurotrophic factor and the risk for dementia: The Framingham Heart Study.” JAMA Neurol. 2014;71(1):55-61

  5. Numakawa T, et al. “Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases.” Int J Mol Sci. 2018 Nov 19;19(11):3650.

  6. Gómez-Pinilla F. “Brain foods: The effects of nutrients on brain function.” Nat Rev Neurosci. 9(7): 568–578. 2008.

  7. Ziaei S, et al. “A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF).” Nutr Neurosci. 2023 Aug 17:1-11.

  8. Ziegenhorn A, et al. “Serum neurotrophins – A study on the time course and influencing factors in a large old age sample.” Neurobiol Aging. 2007;28(9).

  9. Strathearn K, et al. “Neuroprotective effects of anthocyanin- and proanthocyanidinrich extracts in cellular models of Parkinson’s disease.” Brain Res. 2014 Mar 25:1555:60- 77.

  10. Xue B, et al. “Brain-derived neurotrophic factor: a connecting link between nutrition, lifestyle, and Alzheimer’s.” Front Neurosci. 2022 May 25:16:925991.

  11. Lee R, et al. “Regulation of cell survival by secreted proneurotrophins.” Nat Rev Neurosci. 2(5):356-363. 2001.

  12. Lu B, et al. “BDNF and synaptic plasticity, cognitive function, and neuropsychiatric disorders.” Dialogues Clin Neurosci. 2013;15(1) 77-85.

  13. Lim Y, et al. “BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer’s disease.” Neurology. 2009; 79(8):861-868.

  14. Duman RS, et al. “A molecular and cellular theory of depression.” Biol Psychiatry. 2002;52(6):429-442.

  15. Wightman EL, et al. “Acute effects of a polyphenol-rich leaf extract of mangifera indica l. (zynamite) on cognitive function in healthy adults: A double-blind, placebo-controlled crossover study.” Nutrients. 2020 Jul 23;12(8).

  16. Lopez-Rios L, et al. “Central nervous system activities of extract Mangifera indica L.” J Ethnopharmacol. 2020 Oct 5;260:112996.

  17. Lopez-Rios L, et al. “Central nervous system activities of extract Mangifera indica L.” J Ethnopharmacol. 2020 Oct 5;260:112996.

  18. Wightman E, et al. “Acute effects of a polyphenol-rich leaf extract of mangifera indica l. (zynamite) on cognitive function in healthy adults: A double-blind, placebo-controlled crossover study.” Nutrients. 2020 Aug; 12(8): 2194.

  19. Imran M, et al. “Mangiferin: a natural miracle bioactive compound against lifestyle related disorders.” Lipids Health Dis. 2017; 16: 84.

  20. Zhang Y, et al. “Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways.” Food Chem. 2013 Dec 1;141(3):2896-905.

  21. Luo G, et al. “Mangiferin prevents corticosterone-induced behavioural deficits via...activity. Neurol Res. 2017 Aug;39(8):709-718.

  22. Jung H, et al. “Mangifera Indica leaf extracts promote hair growth via activation of Wnt signaling pathway in human dermal papilla cells.” Anim Cells Syst (Seoul). 2022 Jun 11;26(3):129-136.

  23. Gelabert-Rebato M, et al. “A single dose of the mango leaf extract zynamite® in combination with quercetin enhances peak power output during repeated sprint exercise in men and women.” Nutrients. 2019 Oct 28;11(11):2592.