For decades, scientists insisted that it was impossible for your brain to form new neurons — especially in the part of the brain responsible for learning and memory.
But they were wrong.
Today, thanks to a breakthrough study done in 1998 — that’s less than 30 years ago! — we now know that not only is it possible to form new brain cells through a process known as neurogenesis...

But you can also help your existing neurons grow bigger and become more active.1
Sadly, most conventional doctors still insist that forgetfulness, mental fatigue, and fuzzy thinking are just “a normal part of aging.” That’s the usual response from mainstream medicine.
But it’s just not true.
You can easily activate neurogenesis to eliminate brain fog and to stop — and even reverse — memory loss. More on that in a moment.
First, let’s talk about how you can easily activate neurogenesis and reboot your brain’s neurons.
What We Can Learn From “Super-Agers”
An exciting new study is shedding light on how a group of “super-agers” are keeping their brains active and strong.
“Super-ager” is a term for someone whose brain is aging at a rate that’s much slower than average.
In a study published in The Journal of Neuroscience, scientists found that neurons in the area of the brain responsible for memory were noticeably larger in super-agers compared to their peers.2
In fact, the super-agers had larger neurons than some individuals who were 20 to 30 years younger!
The researchers examined neurons located in the entorhinal cortex. That’s the area of the brain whose functions include memory.
The super-agers, who were 80 and older, were compared to cognitively average individuals and those with early-stage Alzheimer’s.
In addition to being large and healthy, the neurons found in the superagers’ brains were relatively free of tau tangles, one of the classic hallmarks of cognitive decline.
Turns out these superagers had turbocharged their brain’s production of brain-derived neurotrophic factor, or BDNF.
This signaling protein and growth factor supports the growth, function, and survival of brain cells — and your brain can’t generate new neurons or make new connections between these brain cells without it.3
It’s like a “growth hormone” for your brain.
It increases the creation and growth of nearly every type of neuron. It also increases the lifespan of existing neurons.4
One study showed that people with the highest levels of BDNF develop dementia 50% less often than people with lower levels.5
Low Levels Of BDNF Lead To So-Called “Senior Moments”
You see, these “senior moments” are not symptoms of aging. They’re symptoms of low levels of the brain chemical BDNF, short for brain-derived neurotrophic factor.
BDNF is a signaling protein and growth factor that supports the growth, function, and survival of brain cells. Your brain can’t generate new neurons or make new connections between them without it.6
When patients at my clinic complain they’re losing their car keys daily or walk into rooms and forget why they’re there, one of my first courses of action is to boost their BDNF.
More than 2,000 peer-reviewed studies link BDNF levels to brain performance, mood, and long-term neurological health.
Researchers have even discovered that the world’s longest-living people all share dietary and lifestyle habits that support high BDNF levels.7
The good news is that it’s easy to raise your levels through diet and supplements.
Here at the Sears Institute for Anti-Aging Medicine, I’ve found that boosting BDNF is the single most powerful way to protect your brain, sharpen your mind, and reverse cognitive decline.
Studies reveal that foods that contain a group of biochemicals called anthocyanins can turbocharge your brain’s production of BDNF.
Consuming grass-fed beef and wild-caught salmon — containing omega-3 fatty acids — are other great ways to boost your BDNF levels.8
But you can do much better. Scientists have recently discovered one special extract that is an even more powerful way to raise BDNF levels and stop cognitive decline.
A Brain Rejuvenator Like No Other
It’s no exaggeration to say that BDNF is the lifeblood of brain health.
This unusual neurotransmitter encourages the growth of new neurons, repairs damaged brain circuits, and even rewires your brain to work better, faster, sharper, and with more resiliency.
You rely on it to:
Form new memories
Regain lost cognitive function
Prevent Alzheimer’s and dementia
Restore your motivation, focus, and emotional balance
The problem is, levels drop off rapidly with age. And if you’re over 50, it’s likely your BDNF levels are already dangerously low.
You see, modern life attacks your brain at every turn. Poor diet, pollution, inflammation, lack of sleep, and chronic stress all suppress your brain’s natural production of BDNF.
Even worse, mainstream medicine does nothing to fix the problem. Their answer to cognitive decline, mental fatigue, and memory loss is a dangerous Big Pharma drug.
But BDNF does something that Big Pharma’s chemicals can never do. BDNF promotes the creation and survival of brain cells.
But BDNF doesn’t just grow new neurons...
The Brain-Drain Medical Doctors Ignore
Imagine your brain is a city. Your neurons are the buildings. Your synapses are the roads and bridges. Your thoughts and memories are the electricity that powers everything.
Now imagine a massive blackout. Lights go out. Communication lines fail. Transportation shuts down. The whole city grinds to a halt.
BDNF decline is the brain drain that no one in mainstream medicine is talking about...
Sadly, this key brain protein begins to drop off around age 30. By the time you hit your 60s, your levels may have declined by more than 50%. Once the decline starts, your brain becomes vulnerable to memory loss, brain fog, depression, mental fatigue and neurodegeneration.9
That’s because when your BDNF levels drop...
Your neurons shrink and die
Your brain can’t form or recall memories
Synaptic communication fails
Emotional regulation goes haywire
Neurodegenerative diseases take root
In fact, brain scans show that people with low BDNF have shrunken hippocampi — the area of the brain that’s responsible for memory and learning.
But higher levels of BDNF produce polar opposite effects. BDNF can light up your brain like a Christmas tree.
Energy flows... Networks connect... And your thoughts move more quickly and clearly.
Increase BDNF To Build New Brain Cells
From the experiences in my clinic, I’ve found the fastest way to bring someone back from the brink of cognitive decline — whether they’re struggling with brain fog and memory loss or they’re experiencing the early signs of Alzheimer’s and Parkinson’s — is to increase their BDNF levels.
Research now reveals that BDNF-boosting foods can be potent weapons against a range of neurodegenerative conditions.
In one study, BDNF-boosting supplements containing anthocyanin extracts helped reduce brain-cell damage from Parkinson’s.10
Researchers have also found that people with Alzheimer’s have lower levels of BDNF than healthy individuals, and that a BDNF-boosting diet can help prevent the condition.11
Here’s what BDNF does to your brain:
Builds New Brain Cells. BDNF activates a process called neurogenesis — the birth of new neurons. For decades, scientists believed we were born with all the brain cells we’d ever have. That’s flat-out false. Your brain can—and will — grow new cells for the rest of your life. But only if BDNF is present.12
Strengthens Synaptic Connections. Learning, memory, mood regulation and critical thinking all depend on the strength of your synaptic connections — the way your neurons communicate with one another. BDNF improves the density, speed, and efficiency of these connections. The more BDNF you have, the faster and clearer your thoughts become.13
Protects Against Alzheimer’s And Neurodegeneration. Low levels of BDNF have been linked directly to Alzheimer’s disease, Parkinson’s, as well as other forms of neurodegeneration. Researchers have also observed that people with the lowest BDNF levels are up to four times more likely to develop Alzheimer’s.14
Fuels Mental Energy And Motivation. Have you ever felt too exhausted to think? Have you struggled to stay motivated or inspired or focused? BDNF activates areas of your brain like the prefrontal cortex and limbic systems. These are the centers responsible for planning, motivation, and emotional balance. When BDNF levels drop, your brain becomes sluggish... your emotions go flat... and everything feels like a chore.15
Helps You Recover From Stress And Trauma. BDNF increases your brain’s resilience. It helps you bounce back from trauma, regulate anxiety, and protect yourself from the long-term effects of chronic stress. Low BDNF has been implicated in depression, PTSD, and burnout.
Boost Your Mind With This Bright Red Berry
I recommend incorporating healthy habits — like regular vigorous exercise, an omega-3 rich diet, increasing the amount of polyphenols you eat, maintaining strong social ties, managing stress, and supplementation — into your daily life.
But you can do even better.

As I mentioned earlier, your brain is not broken... It’s starving for the right nutrients. Scientists have discovered turbo-charged BDNF boosting powers in the humble coffee plant.
I’m not talking about the beans. I’m talking about the bright red berries that grow on the plant itself.
For centuries, this part of the coffee plant was discarded as waste. But researchers have now discovered that these berries contain a combination of extraordinarily high levels of polyphenols and neuroactive compounds, far more than the coffee bean itself.
And here’s the amazing breakthrough...
In a key, double-blind, placebo-controlled study, researchers gave subjects a single dose of whole coffee fruit concentrate powder and then measured their BDNF levels.
The researchers were astonished by the results.
They recorded a jaw-dropping 143% increase in the subjects’ BDNF levels — within a matter of hours.
That’s more than what you get from intense exercise or a healthy intake of omega 3s.
Here is how coffee fruit works:
Activates Brain Stem Cells. Studies show this long-ignored fruit stimulates the release of BDNF, which in turn activates neural stem cells in your brain. These stem cells can morph into brand-new neurons, rebuilding brain pathways damaged by aging, stress, or disease.16
Stops Oxidative Stress. Coffee fruit is packed with powerful antioxidants that protect your neurons from oxidative damage, which triggers inflammation inside your brain. In other words, coffee fruit will help preserve memory, focus, and clarity.17,18
Reduces Inflammation. Chronic brain inflammation is one of the hidden causes of cognitive decline. The polyphenols in coffee fruit calm inflammatory signals and protect your brain’s delicate environment.
Boosts Immunity. Your brain and immune system are intricately linked. Immune cells, especially T cells and microglia, play a crucial role in maintaining brain health by monitoring for pathogens, clearing cellular debris, and supporting neurogenesis and synaptic plasticity.19 Studies show coffee fruit extract increases immune function through its high content of antioxidants and polyphenols.
I suggest supplementing with between 100 mg and 300 mg of coffee fruit extract daily. Look for a product that’s standardized to 40% chlorogenic acid.
Because coffee fruit extract can give you a natural boost of energy, it’s a good idea to take it in the morning or at least avoid taking it at night.

5 More Ways to Give Your Brain An Even Bigger BDNF Boost
While coffee fruit extract is a true powerhouse, it works even better when combined with these other BDNF-boosting nutrients.
DHA – Your Brain’s Favorite Fat. This omega-3 fatty acid upregulates BDNF and supports synaptic plasticity — the brain’s ability to adapt and create new neural pathways. It also increases BDNF levels in the hippocampus, the area of the brain where memories are processed and retrieved.20
DHA is a type of omega-3 fatty acid found in grass-fed meat, squid, and wild-caught salmon, as well as cold-water fish, like herring and mackerel.
I recommend 600 to 1,000 mg of DHA daily.
Lion’s Mane Mushroom. This remarkable mushroom promotes nerve growth factor and BDNF, supporting memory and regeneration. A pilot study of healthy older adults found that supplementing with Lion’s Mane powder for 12 weeks saw significant improvement in cognitive function and prevented decline into dementia.21
Successful clinical trials have used anywhere from 500 mg to 2 grams of Lion’s Mane daily. Start at the lower 500 mg dose for at least one week to see how it affects you, then gradually increase it until you’re seeing noticeable improvements. Look for a standardized extract with at least 30% polysaccharides. It typically takes three to four weeks for the full benefits to kick in.
N-Acetyl-Cysteine (NAC). NAC helps your body produce glutathione, your brain’s master antioxidant. Its anti-inflammatory properties help improve BDNF levels by reducing oxidative stress and inflammation, which can impair BDNF production.22
I recommend taking 600 mg by tablet or capsule per day. After a couple of weeks, you can increase the dosage to 600 mg twice a day.
Bacopa Monnieri. Also called “Herb of Grace,” Bacopa has been used in Ayurvedic medicine for centuries. Studies show that bacopa protects neurons, enhances BDNF signaling, and improves attention, memory, and recall — especially under stress.
In one clinical trial, researchers learned that 12 weeks of supplementing with 300 mg of this bacopa extract significantly improved brain processing speed and the ability to transform short-term into long-term memory.23
I give my patients 300 mg twice a day of Bacopa Monnieri Leaf, standardized to 20% Bacosides.
Curcumin. This is the best anti-inflammatory I’ve ever found, and it has astonishing brain-protective qualities. Recent research has confirmed that curcumin regulates and activates the expression of BDNF.
Studies also show that even low doses of curcumin boost the proliferation and survival of newly generated cells in the hippocampus.24,25
I recommend supplementing with at least 1,000 mg. Look for a product that contains piperine to increase bioavailability. And take it with a full-fat meal.
To Your Good Health,

References:
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eisz J, et al. “The effects of physical exercise and cognitive training on memory and neurotrophic factors.” J Cogn Neurosci. 2017; 29 (11):1895-1907.
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Duman RS, et al. “A molecular and cellular theory of depression.” Biol Psychiatry. 2002;52(6):429-442.
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Aslanlar D, et al. “N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release.” Behav Brain Res. 2024 Feb 26:458:114740.
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